The editors and reviewers here are all science nerds and our passionate pursuit of the best stem cell skin creams on the planet separates us from neurotypicals and puts us somewhere on the spectrum . That being said, we think this whole subject is critically important to survival of the home sapiens species. Especially to skin care aficionados (many of whom also qualify for nerddom). So our desire here is to find a way to communicate all this arcane knowledge into human-usable information. We might not get it right the first time around, so feel free to ask questions or just say say “what???” whenever we obfuscate . We have gathered together a knowledge base which we hope will be helpful.
It is important to note that iPSCs and ESCs are not equivalent. They have many similar properties, such as pluripotency and differentiation potential, the expression of pluripotency genes, epigenetic patterns, embryoid body and teratoma formation, and viable chimera formation.   However, similar does not mean they are the same. In fact, there are many differences within these properties. Importantly, the chromatin of iPSCs appears to be more "closed" or methylated than that of ESCs.   Similarly, the gene expression pattern between ESCs and iPSCs, or even iPSCs sourced from different origins.  There are thus questions about the "completeness" of reprogramming and the somatic memory of induced pluripotent stem cells. Despite this, inducing adult cells to be pluripotent appears to be viable.